Stress Promotes Drug Seeking Through Glucocorticoid-Dependent Endocannabinoid Mobilization in the Prelimbic Cortex
نویسندگان
چکیده
منابع مشابه
Altered prelimbic cortex output during cue-elicited drug seeking.
Cocaine treatment paired with environmental cues establishes a conditioned place preference (CPP) for that environment. After expression of this preference, rats show elevated levels of immediate early genes (IEGs; e.g. c-fos) in the prelimbic cortex (PrL), basolateral amygdala complex (BLC), and nucleus accumbens core (NAcc) compared with drug-unpaired controls. These findings, together with t...
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The ability to regulate emotional responses in various circumstances would provide adaptive advantages for an individual. Using a context-dependent fear discrimination (CDFD) task in which the tone conditioned stimulus (CS) is paired with the footshock unconditioned stimulus (US) in one context but presented alone in another context, we investigated the role of the prelimbic (PL) cortex in cont...
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Prefrontal cortex (PFC) is involved in multiple functions including attentional , spatial orientation, short and long-term memory. Our previous study indicated that microinjection of testosterone in CA1 impaired spatial learning and memory. Some evidence suggests that impairment effect of testosterone is mediated by GABAergic system. In the present study, we investigated the interaction of test...
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Evidence indicates that drug relapse in humans is often provoked by exposure to the self-administered drug-associated context. An animal model called "ABA renewal procedure" has been used to study the context-induced relapse to drug seeking. Here, we reported a new and feasible training procedure for the ABA renewal method to explore the role of the prelimbic cortex in context-induced relapse t...
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Prefrontal cortex (PFC) is involved in multiple functions including attentional , spatial orientation, short and long-term memory. Our previous study indicated that microinjection of testosterone in CA1 impaired spatial learning and memory. Some evidence suggests that impairment effect of testosterone is mediated by GABAergic system. In the present study, we investigated the interaction of test...
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ژورنال
عنوان ژورنال: Biological Psychiatry
سال: 2018
ISSN: 0006-3223
DOI: 10.1016/j.biopsych.2017.09.024